How does Ishiguro present the theme of loss?

The
notion of loss is shown to be one that is intrinsic to the reality of the clones.  Kathy and
Tommy, in particular, are shown to accept the condition of loss as a part of their being.  Loss
is something shown in different lights.  There is the loss shown by what it means to not have
control over one's life or destiny.  The clones experience this loss in the most intense of
manners, understanding that their own life is determined by the want of someone else and that
there is nothing...