How would you design an experiment to chemically change the lysine reside without using dialysis, and what would this show?

Below
are the links to two scientific papers that address different ways to modify aspects of lysines
chemical structure. Because lysine has a primary amine group, it can undergo a lot of possible
reactions (mostly with electrophilic compounds, as primary amines are strong nucleophiles). The
paper by Spicer and...

href="http://www.jbc.org/content/247/18/5703.full.pdf">http://www.jbc.org/content/247/18/5703.full.pdf
href="https://www.nature.com/articles/ncomms5740?error=cookies_not_supported&code=a09075de-4d1b-4e01-8b35-6c457778390c">https://www.nature.com/articles/ncomms5740?error=cookies_...